Actinium is the lowest-atomic-number radioactive metal of the actinide series. It occurs naturally in uranium ores but at extremely low levels—one tonne of uranium ore contains only about 0.2 milligrams of actinium. Even its most stable isotope, actinium-227, has a half-life of only about 21.8 years, so macroscopic quantities cannot be accumulated. Because of its intense radioactivity and extreme scarcity, actinium has no industrial or consumer use. Today it is studied mainly in nuclear chemistry and targeted radiopharmaceutical research, with work underway to explore actinium-225 for targeted alpha therapy.